教員情報
     


  アカギリ サトミ   Akagiri Satomi
  赤桐 里美
   所属   食物栄養学科 食物栄養学科
   職種   准教授
言語種別 英語
発行・発表の年月 2008/04
形態種別 論文
査読 査読あり
標題 Astaxanthin protects mesangial cells from hyperglycemia-induced oxidative signaling.
執筆形態 共著
掲載誌名 J. Cell Biochem
巻・号・頁 103(6),pp.1925-1937
著者・共著者 Manabe E., Handa O., Naito Y., Mizushima K., Akagiri S., Adachi S., Takagi T., Kokura S., Maoka T. and Yoshikawa T.
概要 Astaxanthin (ASX) is a carotenoid that has potent protective effects on diabetic nephropathy in mice model of type 2 diabetes. In this study, we investigated the protective mechanism of ASX on the progression of diabetic nephropathy using an in vitro model of hyperglycemia, focusing on mesangial cells. ASX may prevent the progression of diabetic nephropathy mainly through ROS scavenging effect in mitochondria of mesangial cells and thus is expected to be very useful for the prevention of diabetic nephropathy.