| 教員情報 | |
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カノウ ユリコ
kanou yuriko 狩野 百合子 所属 家政学部 管理栄養士養成課程 職種 教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2017/02 |
| 形態種別 | 論文 |
| 査読 | 査読あり |
| 標題 | Oleuropein aglycone enhancese UCP1 expression inbrown adipose tissue in high fat diet-induced obese rats by activating beta-adrenergic signalling. |
| 執筆形態 | 共著 |
| 掲載誌名 | J. Nutr. Biochem. |
| 掲載区分 | 国外 |
| 出版社・発行元 | Elsecier (Science direct) |
| 巻・号・頁 | 40,pp.209-218 |
| 担当範囲 | First author, Corresponding author |
| 著者・共著者 | ◎Oi-Kano Y, Iwasaki Y, Nakamura T, Watanabe T, Goto T, Kawada T, Watanabe K, Iwai K. |
| 概要 | Oleuropein is the pungent principle of raw olives. Oleuropein aglycone (OA) is amajor phenolic compound in extra virgin olive oil and the absorbed formof oleuropein.
Weaimed to determine the mechanismunderlying the nutritional effects of oleuropein and OA on interscapular brown adipose tissue (IBAT) in ratswith high-fat (HF) diet-induced obesity by examining the agonistic activity of oleuropein and OAtoward the transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1). These findings suggest that OAis the agonist of both TRPA1 and TRPV1 and that OAenhances UCP1 expression in IBAT with a concomitant decrease in the visceral fat mass of HF-diet-induced obese rats through enhanced noradrenaline secretion via beta-adrenergic action following TRPA1 and TRPV1 activation. |
| researchmap用URL | http://dx.doi.org/10.1016/j.jnutbio.2016.11.009 |
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